143 Results for "

Nauclea officinalis (Pirre ex Pitard) Merr.

" in MedChemExpress (MCE) Product Catalog:
Products (143)

143 Results for "Nauclea officinalis (Pirre ex Pitard) Merr." in MCE Product Catalog:

10
Fexaramine
Fexaramine
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10 Publications Verification
Art. -Nr.: HY-10912
CAS. Nr.: 574013-66-4
Reinheit:  99.24%
Target:  

FXR Autophagy

Forschungsgebiete:  

Others

Fexaramine is a potent and selective FXR agonist with an EC50 of 25 nM. Fexaramine has no activity against hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, and hVDR receptors .
7
Magnolol
Magnolol
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7 Cited Publications
Art. -Nr.: HY-N0163
CAS. Nr.: 528-43-8
Category:  

Cardiovascular Disease Neurological Disease Lignans Plants Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:  

RAR/RXR PPAR Autophagy Bacterial

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
6
Cornuside
Cornuside
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6 Cited Publications
Art. -Nr.: HY-N0631
CAS. Nr.: 131189-57-6
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .
4
Asparagusic acid
Asparagusic acid
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4 Cited Publications
Art. -Nr.: HY-50730
CAS. Nr.: 2224-02-4
Category:  

Infection Liliaceae Ketones, Aldehydes, Acids Plants Disease Research Fields Asparagus officinalis L.

Target:  

Parasite Endogenous Metabolite

Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor .
4
Syringaldehyde
Syringaldehyde
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4 Cited Publications
Art. -Nr.: HY-N1390
CAS. Nr.: 134-96-3
Category:  

Microorganisms Monophenols Ketones, Aldehydes, Acids Manihot esculenta Crantz Phenols Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

COX

Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis . Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL . Anti-hyperglycemic and anti-inflammatory activities .
2
Dryocrassin ABBA
Dryocrassin ABBA
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2 Cited Publications
Art. -Nr.: HY-N0530
CAS. Nr.: 12777-70-7
Synonyms: Dryocrassin
Category:  

Infection Dryopteridaceae Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields

Target:  

Apoptosis Influenza Virus

Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase .
2
Verbenalin
Verbenalin
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2 Cited Publications
Art. -Nr.: HY-N2014
CAS. Nr.: 548-37-8
Category:  

Infection Iridoids Verbenaceae Terpenoids Verbena officinalis Linn. Plants Disease Research Fields Inflammation/Immunology

Target:  

SARS-CoV Amyloid-β Ferroptosis Tau Protein Caspase Bcl-2 Family

Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease .
2
Monotropein
Monotropein
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2 Cited Publications
Art. -Nr.: HY-N0648
CAS. Nr.: 5945-50-6
Category:  

Iridoids Pyrola calliantha H. Andr. Terpenoids Pyrolaceae Rubiaceae Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .
1
5-Hydroxymethylfurfural
5-Hydroxymethylfurfural
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1 Cited Publications
Art. -Nr.: HY-Y0051
CAS. Nr.: 67-47-0
Synonyms: 2-Hydroxymethyl-5-furfural; 2-Formyl-5-hydroxymethylfuran
Category:  

Cornaceae Cornus officinalis Sieb. et Zucc. Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields

Target:  

Fungal

5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
1
Luteolin 7-diglucuronide
Luteolin 7-diglucuronide
0 Images
1 Cited Publications
Art. -Nr.: HY-N7269
CAS. Nr.: 96400-45-2
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase AMPK

Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis .
1
Methyl carnosate
Methyl carnosate
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1 Cited Publications
Art. -Nr.: HY-136150
CAS. Nr.: 82684-06-8
Category:  

Infection Labiatae Terpenoids Samanea saman (Jacq.) Merr. Phenols Polyphenols Diterpenoids Plants Disease Research Fields

Target:  

Bacterial

Methyl camosate is a diterpene isolated from Salvia officinalis or Rosmarinus officinalis. Methyl camosate has potent antioxidant and anti-bacterial activity .
1
3-Epioleanolic acid
3-Epioleanolic acid
0 Images
1 Cited Publications
Art. -Nr.: HY-N4290
CAS. Nr.: 25499-90-5
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

3-Epioleanolic acid is an active component of Verbena officinalis Linn, with anti-inflammatory activity .
1
11,12-Di-O-methylcarnosol
11,12-Di-O-methylcarnosol
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1 Cited Publications
Art. -Nr.: HY-N12492
CAS. Nr.: 25460-12-2
Category:  

Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Terpenoids Diterpenoids Plants

Target:  

Others

11,12-Di-O-methylcarnosol (Comp 7) is a nolic diterpene lactone that can be isolated from leaves of rosemary (Rosmarinus officinalis L.) .
1
Isorosmanol
Isorosmanol
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1 Cited Publications
Art. -Nr.: HY-N4191
CAS. Nr.: 93780-80-4
Category:  

Neurological Disease Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Terpenoids Phenols Polyphenols Diterpenoids Plants Disease Research Fields

Target:  

Cholinesterase (ChE)

Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis .
1
Ziyuglycoside II
Ziyuglycoside II
0 Images
1 Cited Publications
Art. -Nr.: HY-N0332
CAS. Nr.: 35286-59-0
Category:  

Triterpenes Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Apoptosis

Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect .
1
β-Glucogallin
β-Glucogallin
0 Images
1 Cited Publications
Art. -Nr.: HY-133708
CAS. Nr.: 13405-60-2
Reinheit:  99.82%
Synonyms: Glucogallin; 1-O-Galloyl-β-D-glucose
Category:  

Phyllanthaceae Phenols Polyphenols Phyllanthus emblica L. Plants

Target:  

Aldose Reductase Reactive Oxygen Species (ROS) NF-κB PDGFR SOD

β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC50 value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research .
1
Ziyuglycoside I
Ziyuglycoside I
0 Images
1 Cited Publications
Art. -Nr.: HY-N0331
CAS. Nr.: 35286-58-9
Category:  

Triterpenes Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Disease Research Fields Cancer

Target:  

MDM-2/p53 Apoptosis

Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .
Luteolin-3-O-beta-D-glucuronide
Luteolin-3-O-beta-D-glucuronide
0 Images
Art. -Nr.: HY-N4099
CAS. Nr.: 53527-42-7
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Drug Metabolite

Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .
Hastatoside
Hastatoside
0 Images
Art. -Nr.: HY-N2015
CAS. Nr.: 50816-24-5
Category:  

Iridoids Verbenaceae Terpenoids Verbena officinalis Linn. Plants

Target:  

Others

Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep .
Strictosamide
Strictosamide
0 Images
Art. -Nr.: HY-N1198
CAS. Nr.: 23141-25-5
Category:  

Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Rubiaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids

Target:  

Parasite Fungal NO Synthase Interleukin Related NF-κB p38 MAPK Na+/K+ ATPase PERK JNK Akt PI3K

Strictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing .
Assay Types